Margaret Qualley has been talking about the lasting impact of wearing prosthetics for her role in The Substance. She plays Sue in the body horror movie and shared on the Happy Sad Confused podcast that her skin stayed damaged for almost a year after she finished filming.
Margaret Qualley explained to host Josh Horowitz,
Like, at the end, when they’re shooting up my skirt in the beginning credits, when it’s like the palm trees all around and they have all these long lenses from the bottom, that’s just because my face was so fucked up by that time that they couldn’t, like, shoot my face anymore.
The Once Upon a Time in Hollywood actress shared that she was still dealing with acne from the prosthetics when she started filming her next movie, Kinds of Kindness.
So, you know the character that has all that acne? That was just my acne from the prosthetics. And I was like, ‘Oh, this is kind of perfect. I’m playing all these different characters — for one of them we’ll use all my crazy prosthetic acne.’ It took me probably a year to recover physically from all of it.
She said,

The Substance, which also stars Demi Moore and Dennis Quaid, tells the story of a fading celebrity who uses a black-market drug: a substance that replicates cells and temporarily makes her look younger and better.
See More: Coralie Fargeat Says There Will Not Be A Sequel To ‘THE SUBSTANCE’
Production designer Pierre Olivier-Persin explained to The Hollywood Reporter that Qualley also wore fake breasts in the movie, created by taking a live cast of the actress.
It’s pretty much the same process for every prosthetic: You start with the live cast or scan, then you sculpt the change you want to achieve, and then you mold those sculptures. After that, you use silicon or whatever material you’re working with, stick them on, and paint them.
He said